2BBB

Structure of HIV1 protease and hh1_173_3a complex.

Summary for 2BBB

Entry DOI	10.2210/pdb2bbb/pdb
Descriptor	Protease, (3S)-TETRAHYDROFURAN-3-YL (1R)-3-{(2R)-4-[(1S,3S)-3-(2-AMINO-2-OXOETHYL)-2,3-DIHYDRO-1H-INDEN-1-YL]-2-BENZYL-3-OXO-2,3-DIHYDRO-1H-PYRROL-2-YL}-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
Functional Keywords	protease, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22231.25
Authors	Smith III, A.B.,Charnley, A.K.,Kuo, L.C.,Munshi, S. (deposition date: 2005-10-17, release date: 2005-11-15, Last modification date: 2023-08-23)
Primary citation	Smith III, A.B.,Charnley, A.K.,Harada, H.,Beiger, J.J.,Cantin, L.D.,Kenesky, C.S.,Hirschmann, R.,Munshi, S.,Olsen, D.B.,Stahlhut, M.W.,Schleif, W.A.,Kuo, L.C. Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains Bioorg.Med.Chem.Lett., 16:859-863, 2006 Cited by PubMed: 16298527 DOI: 10.1016/j.bmcl.2005.11.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation