2B7G

Structure of the Smaug Recognition RNA Element

Summary for 2B7G

• Entry DOI: 10.2210/pdb2b7g/pdb
• Related: 2B6G
• Descriptor: 5'-R(*GP*GP*AP*GP*GP*CP*UP*CP*UP*GP*GP*CP*AP*GP*CP*UP*UP*UP*C)-3' (1 entity in total)
• Functional Keywords: rna, protein-rna complex
• Total number of polymer chains: 1
• Total formula weight: 6086.63

Authors

Johnson, P.E.,Donaldson, L.W. (deposition date: 2005-10-04, release date: 2006-01-24, Last modification date: 2024-05-22)

Primary citation

Johnson, P.E.,Donaldson, L.W.
RNA recognition by the Vts1p SAM domain
Nat.Struct.Mol.Biol., 13:177-178, 2006

PubMed Abstract: The putative yeast post-transcriptional regulator Vts1p and its related protein Smaug, from Drosophila melanogaster, each use a sterile alpha motif (SAM) domain to bind an RNA hairpin termed the Smaug recognition element (SRE). Here, we present the NMR structures of the Vts1p-SRE complex and the free SRE. Structural highlights include the direct recognition of a guanine base and the formation or stabilization of a base pair in the SRE loop.

PubMed: 16429155
DOI: 10.1038/nsmb1039

Experimental method

SOLUTION NMR