2B6A

Crystal structure of HIV-1 reverse transcriptase (RT) in complex with THR-50

Summary for 2B6A

• Entry DOI: 10.2210/pdb2b6a/pdb
• Related: 2B5J
• Descriptor: Reverse transcriptase p66 subunit, Reverse transcriptase p51 subunit, 1-(2,6-DIFLUOROBENZYL)-2-(2,6-DIFLUOROPHENYL)-4-METHYL-1H-BENZIMIDAZOLE (3 entities in total)
• Functional Keywords: aids, hiv, drug design, reverse transcriptase, rt, protein-inhibitor complex, transferase
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• Total number of polymer chains: 2
• Total formula weight: 115153.07

Authors

Morningstar, M.L.,Roth, T.,Smith, M.K.,Zajac, M.,Watson, K.,Buckheit, R.W.,Das, K.,Zhang, W.,Arnold, E.,Michejda, C.J. (deposition date: 2005-09-30, release date: 2005-11-01, Last modification date: 2023-08-23)

• Primary citation: Morningstar, M.L.,Roth, T.,Smith, M.K.,Zajac, M.,Watson, K.,Buckheit, R.W.,Das, K.,Zhang, W.,Arnold, E.,Michejda, C.J.; Crystal structure of HIV-1 reverse transcriptase (RT) in complex with THR-50; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.65 Å)