2B6A
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with THR-50
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase p66 subunit | polymer | 560 | 64501.0 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus 1 | HIV-1 RT |
| 2 | B (B) | Reverse transcriptase p51 subunit | polymer | 430 | 50281.8 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus 1 | HIV-1 RT |
| 3 | C (A) | 1-(2,6-DIFLUOROBENZYL)-2-(2,6-DIFLUOROPHENYL)-4-METHYL-1H-BENZIMIDAZOLE | non-polymer | 370.3 | 1 | Chemie (T50) |
Sequence modifications
A: 1 - 560 (UniProt: P03366)
B: 1 - 430 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 614 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 614 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 114782.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 370.3 | |
| All* | Total formula weight | 115153.1 |
