2B6A

Crystal structure of HIV-1 reverse transcriptase (RT) in complex with THR-50

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Reverse transcriptase p66 subunit	polymer	560	64501.0	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus 1	HIV-1 RT
2	B	Reverse transcriptase p51 subunit	polymer	430	50281.8	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus 1	HIV-1 RT
3	A	1-(2,6-DIFLUOROBENZYL)-2-(2,6-DIFLUOROPHENYL)-4-METHYL-1H-BENZIMIDAZOLE	non-polymer		370.3	1	Chemie (T50)

Sequence modifications

A: 1 - 560 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 614	engineered mutation

B: 1 - 430 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 614	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	114782.7
Non-Polymers*	Number of molecules	1
	Total formula weight	370.3
All*	Total formula weight	115153.1

*Water molecules are not included.