2B54

Human cyclin dependent kinase 2 (CKD2)complexed with DIN-232305

Summary for 2B54

Related2B52 2B53 2B55
DescriptorCell division protein kinase 2, 6-(3,4-DIHYDROXYBENZYL)-3-ETHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE (3 entities in total)
Functional Keywordsprotein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34442.2
Authors
Chang, C.-C. (deposition date: 2005-09-27, release date: 2005-10-11, Last modification date: 2011-07-13)
Primary citation
Markwalder, J.A.,Arnone, M.R.,Benfield, P.A.,Boisclair, M.,Burton, C.R.,Chang, C.-C.,Cox, S.S.,Czerniak, P.M.,Dean, C.L.,Dolenaik, D.,Grafstrom, R.,Harrison, B.A.,Kaltenbach III, R.F.,Nugiel, D.A.,Rossi, K.A.,Sherk, S.R.,Sisk, L.M.,Stouten, P.,Trainor, G.L.,Worland, P.,Seitz, S.P.
Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1h-pyraxolo[3,4-d]pyrimidin-4-one inhibitors of cyclin dependent kinases
J.Med.Chem., 47:5894-5911, 2004
PubMed: 15537345 (PDB entries with the same primary citation)
DOI: 10.1021/jm020455u
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.317152.7%24.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report