2B54

Human cyclin dependent kinase 2 (CKD2)complexed with DIN-232305

2B54 の概要

• エントリーDOI: 10.2210/pdb2b54/pdb
• 関連するPDBエントリー: 2B52 2B53 2B55
• 分子名称: Cell division protein kinase 2, 6-(3,4-DIHYDROXYBENZYL)-3-ETHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE (3 entities in total)
• 機能のキーワード: protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34442.20

構造登録者

Chang, C.-C. (登録日: 2005-09-27, 公開日: 2005-10-11, 最終更新日: 2024-04-03)

• 主引用文献: Markwalder, J.A.,Arnone, M.R.,Benfield, P.A.,Boisclair, M.,Burton, C.R.,Chang, C.-C.,Cox, S.S.,Czerniak, P.M.,Dean, C.L.,Dolenaik, D.,Grafstrom, R.,Harrison, B.A.,Kaltenbach III, R.F.,Nugiel, D.A.,Rossi, K.A.,Sherk, S.R.,Sisk, L.M.,Stouten, P.,Trainor, G.L.,Worland, P.,Seitz, S.P.; Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1h-pyraxolo[3,4-d]pyrimidin-4-one inhibitors of cyclin dependent kinases; J.Med.Chem., 47:5894-5911, 2004; PubMed: 15537345; DOI: 10.1021/jm020455u

実験手法

X-RAY DIFFRACTION (1.85 Å)