Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325

Summary for 2B53

Related2B52 2B54 2B55
DescriptorCell division protein kinase 2, 6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE (3 entities in total)
Functional Keywordsprotein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34336.86
Muckelbauer, J. (deposition date: 2005-09-27, release date: 2005-10-11, Last modification date: 2011-07-13)
Primary citation
Sielecki, T.M.,Johnson, T.L.,Liu, J.,Muckelbauer, J.K.,Grafstrom, R.H.,Cox, S.,Boylan, J.,Burton, C.R.,Chen, H.,Smallwood, A.,Chang, C.-H.,Boisclair, M.,Benfield, P.A.,Trainor, G.L.,Seitz, S.P.
Quinazolines as Cyclin Dependent Kinase Inhibitors
Bioorg.Med.Chem.Lett., 11:1157-1160, 2001
PubMed: 11354366 (PDB entries with the same primary citation)
DOI: 10.1016/S0960-894X(01)00185-8
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.273160.7%7.3%11.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report