2B53

Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325

2B53 の概要

• エントリーDOI: 10.2210/pdb2b53/pdb
• 関連するPDBエントリー: 2B52 2B54 2B55
• 分子名称: Cell division protein kinase 2, 6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE (3 entities in total)
• 機能のキーワード: protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34336.86

構造登録者

Muckelbauer, J. (登録日: 2005-09-27, 公開日: 2005-10-11, 最終更新日: 2024-02-14)

主引用文献

Sielecki, T.M.,Johnson, T.L.,Liu, J.,Muckelbauer, J.K.,Grafstrom, R.H.,Cox, S.,Boylan, J.,Burton, C.R.,Chen, H.,Smallwood, A.,Chang, C.-H.,Boisclair, M.,Benfield, P.A.,Trainor, G.L.,Seitz, S.P.
Quinazolines as Cyclin Dependent Kinase Inhibitors
Bioorg.Med.Chem.Lett., 11:1157-1160, 2001

PubMed Abstract: Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.

PubMed: 11354366
DOI: 10.1016/S0960-894X(01)00185-8

実験手法

X-RAY DIFFRACTION (2 Å)