2B4S

Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase

2B4S の概要

• エントリーDOI: 10.2210/pdb2b4s/pdb
• 分子名称: Tyrosine-protein phosphatase, non-receptor type 1, Insulin receptor, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hydrolase/transferase, phosphorylation, tyrosine protein kinase, hydrolase-transferase complex
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031; Membrane; Single-pass type I membrane protein: P06213
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 140404.96

構造登録者

Li, S.,Depetris, R.S.,Barford, D.,Chernoff, J.,Hubbard, S.R. (登録日: 2005-09-26, 公開日: 2005-11-15, 最終更新日: 2023-11-15)

• 主引用文献: Li, S.,Depetris, R.S.,Barford, D.,Chernoff, J.,Hubbard, S.R.; Crystal Structure of a Complex between Protein Tyrosine Phosphatase 1B and the Insulin Receptor Tyrosine Kinase.; Structure, 13:1643-1651, 2005; PubMed: 16271887; DOI: 10.1016/j.str.2005.07.019

実験手法

X-RAY DIFFRACTION (2.3 Å)