2B4J

Structural basis for the recognition between HIV-1 integrase and LEDGF/p75

Summary for 2B4J

• Entry DOI: 10.2210/pdb2b4j/pdb
• Related: 1ITG 1K6Y 1z9e
• Descriptor: Integrase (IN), PC4 and SFRS1 interacting protein, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: hiv, integration, transcription, viral protein, recombination
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P12497; Nucleus : O75475
• Total number of polymer chains: 4
• Total formula weight: 59524.24

Authors

Cherepanov, P.,Ambrosio, A.L.,Rahman, S.,Ellenberger, T.,Engelman, A. (deposition date: 2005-09-24, release date: 2005-10-25, Last modification date: 2023-08-23)

• Primary citation: Cherepanov, P.,Ambrosio, A.L.,Rahman, S.,Ellenberger, T.,Engelman, A.; Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75; Proc.Natl.Acad.Sci.Usa, 102:17308-17313, 2005; PubMed: 16260736; DOI: 10.1073/pnas.0506924102

Experimental method

X-RAY DIFFRACTION (2.02 Å)