2B36

Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by 5-pentyl-2-phenoxyphenol

Summary for 2B36

• Entry DOI: 10.2210/pdb2b36/pdb
• Related: 1BVR 1ENY 1ENZ 1P44 1P45 1ZID
• Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH], 5-PENTYL-2-PHENOXYPHENOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
• Functional Keywords: enoyl reductase, oxidoreductase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 6
• Total formula weight: 176847.27

Authors

Sullivan, T.J.,Truglio, J.J.,Novichenok, P.,Stratton, C.,Zhang, X.,Kaur, T.,Johnson, F.,Boyne, M.S.,Amin, A. (deposition date: 2005-09-19, release date: 2006-03-07, Last modification date: 2024-02-14)

• Primary citation: Sullivan, T.J.,Truglio, J.J.,Boyne, M.E.,Novichenok, P.,Zhang, X.,Stratton, C.,Li, H.J.,Kaur, T.,Amin, A.,Johnson, F.,Slayden, R.A.,Kisker, C.,Tonge, P.J.; High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis; ACS Chem.Biol., 1:43-53, 2006

Experimental method

X-RAY DIFFRACTION (2.8 Å)