2B17

Specific binding of non-steroidal anti-inflammatory drugs (NSAIDs) to phospholipase A2: Crystal structure of the complex formed between phospholipase A2 and diclofenac at 2.7 A resolution:

Summary for 2B17

• Entry DOI: 10.2210/pdb2b17/pdb
• Related: 1Q7A
• Descriptor: Phospholipase A2 VRV-PL-VIIIa, SULFATE ION, 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, ... (4 entities in total)
• Functional Keywords: drugs, complex, inhibiton, hydrolase
• Biological source: Daboia russellii pulchella
• Cellular location: Secreted: P59071
• Total number of polymer chains: 1
• Total formula weight: 14118.04

Authors

Singh, N.,Jabeen, T.,Sharma, S.,Singh, T.P. (deposition date: 2005-09-15, release date: 2005-10-04, Last modification date: 2011-07-13)

• Primary citation: Singh, N.,Jabeen, T.,Sharma, S.,Somvanshi, R.K.,Dey, S.,Srinivasan, A.,Singh, T.P.; Specific binding of non-steroidal anti-inflammatory drugs (NSAIDs) to phospholipase A2: structure of the complex formed between phospholipase A2 and diclofenac at 2.7 A resolution.; Acta Crystallogr.,Sect.D, 62:410-416, 2006; PubMed: 16552142; DOI: 10.1107/S0907444906003660

Experimental method

X-RAY DIFFRACTION (2.71 Å)