2B0U

The Structure of the Follistatin:Activin Complex

2B0U の概要

• エントリーDOI: 10.2210/pdb2b0u/pdb
• 分子名称: Inhibin beta A chain, Follistatin, IRIDIUM (III) ION, ... (6 entities in total)
• 機能のキーワード: activin, follistatin, tgf-beta, morphogen, inhibin, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P08476 P19883
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 90655.58

構造登録者

Thompson, T.B.,Lerch, T.F.,Cook, R.W.,Woodruff, T.K.,Jardetzky, T.S. (登録日: 2005-09-14, 公開日: 2005-10-11, 最終更新日: 2024-10-30)

主引用文献

Thompson, T.B.,Lerch, T.F.,Cook, R.W.,Woodruff, T.K.,Jardetzky, T.S.
The Structure of the Follistatin:Activin Complex Reveals Antagonism of Both Type I and Type II Receptor Binding.
Dev.Cell, 9:535-543, 2005

PubMed Abstract: TGF-beta ligands stimulate diverse cellular differentiation and growth responses by signaling through type I and II receptors. Ligand antagonists, such as follistatin, block signaling and are essential regulators of physiological responses. Here we report the structure of activin A, a TGF-beta ligand, bound to the high-affinity antagonist follistatin. Two follistatin molecules encircle activin, neutralizing the ligand by burying one-third of its residues and its receptor binding sites. Previous studies have suggested that type I receptor binding would not be blocked by follistatin, but the crystal structure reveals that the follistatin N-terminal domain has an unexpected fold that mimics a universal type I receptor motif and occupies this receptor binding site. The formation of follistatin:BMP:type I receptor complexes can be explained by the stoichiometric and geometric arrangement of the activin:follistatin complex. The mode of ligand binding by follistatin has important implications for its ability to neutralize homo- and heterodimeric ligands of this growth factor family.

PubMed: 16198295
DOI: 10.1016/j.devcel.2005.09.008

実験手法

X-RAY DIFFRACTION (2.8 Å)