2B07

Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.

Summary for 2B07

Entry DOI	10.2210/pdb2b07/pdb
Related	2AZR
Descriptor	Tyrosine-protein phosphatase, non-receptor type 1, 6-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}-3-(CARBOXYMETHOXY)THIENO[3,2-B][1]BENZOTHIOPHENE-2-CARBOXYLIC ACID (3 entities in total)
Functional Keywords	protein tyrosine phosphatase, hydrolyase, tricyclic thiophenes, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	35394.38
Authors	Moretto, A.F.,Kirincich, S.J.,Xu, W.X.,Smith, M.J.,Wan, Z.K.,Wilson, D.P.,Follows, B.C.,Binnun, E.,Joseph-McCarthy, D.,Foreman, K.,Erbe, D.V.,Zhang, Y.L.,Tam, S.K.,Tam, S.Y.,Lee, J. (deposition date: 2005-09-13, release date: 2005-12-06, Last modification date: 2024-02-14)
Primary citation	Moretto, A.F.,Kirincich, S.J.,Xu, W.X.,Smith, M.J.,Wan, Z.K.,Wilson, D.P.,Follows, B.C.,Binnun, E.,Joseph-McCarthy, D.,Foreman, K.,Erbe, D.V.,Zhang, Y.L.,Tam, S.K.,Tam, S.Y.,Lee, J. Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors. Bioorg.Med.Chem., 14:2162-2177, 2006 Cited by PubMed: 16303309 DOI: 10.1016/j.bmc.2005.11.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation