2AVT

Crystal structure of the beta subunit from DNA polymerase of Streptococcus pyogenes

2AVT の概要

• エントリーDOI: 10.2210/pdb2avt/pdb
• 分子名称: DNA polymerase III beta subunit (2 entities in total)
• 機能のキーワード: beta clamp, sliding clamp, polymerase, replication, transferase
• 由来する生物種: Streptococcus pyogenes
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83885.12

構造登録者

Argiriadi, M.A.,Goedken, E.R.,Bruck, I.,O'donnell, M.,Kuriyan, J. (登録日: 2005-08-30, 公開日: 2006-01-24, 最終更新日: 2024-02-14)

主引用文献

Argiriadi, M.A.,Goedken, E.R.,Bruck, I.,O'donnell, M.,Kuriyan, J.
Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium.
Bmc Struct.Biol., 6:2-2, 2006

PubMed Abstract: Sliding DNA clamps are processivity factors that are required for efficient DNA replication. DNA polymerases maintain proximity to nucleic acid templates by interacting with sliding clamps that encircle DNA and thereby link the polymerase enzyme to the DNA substrate. Although the structures of sliding clamps from Gram-negative bacteria (E. coli), eukaryotes, archaea, and T4-like bacteriophages are well-known, the structure of a sliding clamp from Gram-positive bacteria has not been reported previously.

PubMed: 16403212
DOI: 10.1186/1472-6807-6-2

実験手法

X-RAY DIFFRACTION (2 Å)