2ARW

The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor

Summary for 2ARW

• Entry DOI: 10.2210/pdb2arw/pdb
• NMR Information: BMRB: 5940
• Descriptor: Interleukin-6 receptor alpha chain (1 entity in total)
• Functional Keywords: fibronectin-type iii like, cytokine
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 14680.38

Authors

Hecht, O.,Dingley, A.J.,Schwantner, A.,Ozbek, S.,Rose-John, S.,Grotzinger, J. (deposition date: 2005-08-22, release date: 2006-09-12, Last modification date: 2024-05-01)

Primary citation

Hecht, O.,Dingley, A.J.,Schwanter, A.,Ozbek, S.,Rose-John, S.,Grotzinger, J.
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor
Biol.Chem., 387:1255-1259, 2006

PubMed Abstract: The members of the interleukin-6-type family of cytokines interact with receptors that have a modular structure and are built of several immunoglobulin-like and fibronectin type III-like domains. These receptors have a characteristic cytokine receptor homology region consisting of two fibronectin type III-like domains defined by a set of four conserved cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On target cells, interleukin-6 (IL-6) initially binds to its cognate alpha-receptor and subsequently to a homodimer of the signal transducer receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular domains. The N-terminal immunoglobulin-like domain is not involved in ligand binding, whereas the third membrane-proximal fibronectin-like domain (IL-6R-D3) accounts for more than 90% of the binding energy to IL-6. Here, we present the solution structure of the IL-6R-D3 domain solved by multidimensional heteronuclear NMR spectroscopy.

PubMed: 16972794
DOI: 10.1515/BC.2006.155

Experimental method

SOLUTION NMR