2AQI

Crystal structure of Isoniazid-resistant I47T Enoyl-ACP(CoA) reductase mutant enzyme from Mycobacterium tuberculosis in complex with NADH

2AQI の概要

• エントリーDOI: 10.2210/pdb2aqi/pdb
• 関連するPDBエントリー: 1ENY 2AQH 2AQK
• 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE (3 entities in total)
• 機能のキーワード: enoyl-acyl carrier protein, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29208.17

構造登録者

Oliveira, J.S.,Pereira, J.H.,Rodrigues, N.C.,Canduri, F.,de Souza, O.N.,Basso, L.A.,de Azevedo Jr., W.F.,Santos, D.S. (登録日: 2005-08-18, 公開日: 2006-05-23, 最終更新日: 2024-05-29)

• 主引用文献: Oliveira, J.S.,Pereira, J.H.,Canduri, F.,Rodrigues, N.C.,de Souza, O.N.,de Azevedo Jr., W.F.,Basso, L.A.,Santos, D.S.; Crystallographic and Pre-steady-state Kinetics Studies on Binding of NADH to Wild-type and Isoniazid-resistant Enoyl-ACP(CoA) Reductase Enzymes from Mycobacterium tuberculosis.; J.Mol.Biol., 359:646-666, 2006; PubMed: 16647717; DOI: 10.1016/j.jmb.2006.03.055

実験手法

X-RAY DIFFRACTION (2.2 Å)