2AQI
Crystal structure of Isoniazid-resistant I47T Enoyl-ACP(CoA) reductase mutant enzyme from Mycobacterium tuberculosis in complex with NADH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Enoyl-[acyl-carrier-protein] reductase [NADH] | polymer | 269 | 28542.7 | 1 | UniProt (P0A5Y6) Pfam (PF13561) UniProt (by SIFTS) (P9WGR1) | Mycobacterium tuberculosis | NADH-dependent enoyl-ACP reductase |
| 2 | B (A) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 1 | Chemie (NAI) PubChem (16219774) PubChem (928) PubChem (44119956) PubChem (44415182) PubChem (439153) PubChem (124934832) PubChem (126455899) PubChem (94865921) PubChem (94865923) PubChem (134693949) PubChem (12309339) PubChem (12309347) PubChem (124432988) PubChem (140875346) PubChem (11250888) PubChem (12309341) PubChem (124934831) PubChem (124934833) PubChem (162951601) PubChem (162951600) PubChem (164575491) PubChem (169545638) PubChem (170905224) PubChem (174316169) PubChem (129607000) PubChem (129628338) PubChem (146167236) PubChem (162951602) PubChem (174084875) | |||
| 3 | C (A) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A: 1 - 269 (UniProt: P0A5Y6)
| PDB | External Database | Details |
|---|---|---|
| Thr 47 | Ile 47 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28542.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 665.4 | |
| All* | Total formula weight | 29208.2 |
