2AQI
Crystal structure of Isoniazid-resistant I47T Enoyl-ACP(CoA) reductase mutant enzyme from Mycobacterium tuberculosis in complex with NADH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Enoyl-[acyl-carrier-protein] reductase [NADH] | polymer | 269 | 28542.7 | 1 | UniProt (P0A5Y6) Pfam (PF13561) UniProt (by SIFTS) (P9WGR1) In PDB | Mycobacterium tuberculosis | NADH-dependent enoyl-ACP reductase |
| 2 | A | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 1 | Chemie (NAI) | |||
| 3 | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A: 1 - 269 (UniProt: P0A5Y6)
| PDB | External Database | Details |
|---|---|---|
| Thr 47 | Ile 47 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28542.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 665.4 | |
| All* | Total formula weight | 29208.2 |
