2AO6
Crystal structure of the human androgen receptor ligand binding domain bound with TIF2(iii) 740-753 peptide and R1881
Replaces: 1XQ2Summary for 2AO6
Entry DOI | 10.2210/pdb2ao6/pdb |
Related | 1XOW 1XQ3 |
Descriptor | androgen receptor, 14-mer fragment of Nuclear receptor coactivator 2, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE, ... (4 entities in total) |
Functional Keywords | crystal structure; human androgen receptor ligand binding domain; transcriptional intermediary factor 2 740-753; r188, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P10275 Q15596 |
Total number of polymer chains | 2 |
Total formula weight | 32140.68 |
Authors | He, B.,Gampe Jr., R.T.,Kole, A.J.,Hnat, A.T.,Stanley, T.B.,An, G.,Stewart, E.L.,Kalman, R.I.,Minges, J.T.,Wilson, E.M. (deposition date: 2005-08-12, release date: 2005-08-30, Last modification date: 2023-08-23) |
Primary citation | He, B.,Gampe Jr., R.T.,Kole, A.J.,Hnat, A.T.,Stanley, T.B.,An, G.,Stewart, E.L.,Kalman, R.I.,Minges, J.T.,Wilson, E.M. Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance Mol.Cell, 16:425-438, 2004 Cited by PubMed: 15525515DOI: 10.1016/j.molcel.2004.09.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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