2ANL

X-ray crystal structure of the aspartic protease plasmepsin 4 from the malarial parasite plasmodium malariae bound to an allophenylnorstatine based inhibitor

2ANL の概要

• エントリーDOI: 10.2210/pdb2anl/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000566
• 分子名称: plasmepsin IV, (4R)-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide (3 entities in total)
• 機能のキーワード: plasmodium parasite, plasmepsin 4, aspartic protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Plasmodium malariae
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75413.09

構造登録者

Clemente, J.C.,Govindasamy, L.,Madabushi, A.,Fisher, S.Z.,Moose, R.E.,Yowell, C.A.,Hidaka, K.,Kimura, T.,Hayashi, Y.,Kiso, Y.,Agbandje-McKenna, M.,Dame, J.B.,Dunn, B.M.,McKenna, R. (登録日: 2005-08-11, 公開日: 2006-04-04, 最終更新日: 2024-04-03)

• 主引用文献: Clemente, J.C.,Govindasamy, L.,Madabushi, A.,Fisher, S.Z.,Moose, R.E.,Yowell, C.A.,Hidaka, K.,Kimura, T.,Hayashi, Y.,Kiso, Y.,Agbandje-McKenna, M.,Dame, J.B.,Dunn, B.M.,McKenna, R.; Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.; Acta Crystallogr.,Sect.D, 62:246-252, 2006; PubMed: 16510971; DOI: 10.1107/S0907444905041260

実験手法

X-RAY DIFFRACTION (3.3 Å)