2AN5

Structure of human PNMT complexed with S-adenosyl-homocysteine and an inhibitor, trans-(1S,2S)-2-amino-1-tetralol

2AN5 の概要

• エントリーDOI: 10.2210/pdb2an5/pdb
• 関連するPDBエントリー: 1HNN 1N7I 1N7J 1YZ3 2AN3 2AN4
• 分子名称: Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL, ... (5 entities in total)
• 機能のキーワード: methyltransferase, inhibitor structure, s-adenosyl-l-methionine, adrenaline synthesis, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64882.16

構造登録者

Gee, C.L.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L. (登録日: 2005-08-11, 公開日: 2006-03-14, 最終更新日: 2023-10-25)

• 主引用文献: Gee, C.L.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L.; Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis; Biochemistry, 44:16875-16885, 2005; PubMed: 16363801; DOI: 10.1021/bi051636b

実験手法

X-RAY DIFFRACTION (2.5 Å)