2AN4

Structure of PNMT complexed with S-adenosyl-L-homocysteine and the acceptor substrate octopamine

2AN4 の概要

• エントリーDOI: 10.2210/pdb2an4/pdb
• 関連するPDBエントリー: 1HNN 1N7I 1N7J 1YZ3 2AN3 2AN5
• 分子名称: Phenylethanolamine N-methyltransferase, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
• 機能のキーワード: methyltransferase, substrate structure, s-adenosyl-l-methionine, adrenaline synthesis, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64862.08

構造登録者

Gee, C.L.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L. (登録日: 2005-08-11, 公開日: 2006-03-14, 最終更新日: 2023-10-25)

• 主引用文献: Gee, C.L.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L.; Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis; Biochemistry, 44:16875-16885, 2005; PubMed: 16363801; DOI: 10.1021/bi051636b

実験手法

X-RAY DIFFRACTION (2.2 Å)