2AN4
Structure of PNMT complexed with S-adenosyl-L-homocysteine and the acceptor substrate octopamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Phenylethanolamine N-methyltransferase | polymer | 289 | 31846.0 | 2 | UniProt (P11086) Pfam (PF01234) | Homo sapiens (human) | PNMTase, Noradrenaline N-methyltransferase |
| 2 | C (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 3 | D, F (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 4 | E, G (A, B) | 4-(2R-AMINO-1-HYDROXYETHYL)PHENOL | non-polymer | 153.2 | 2 | Chemie (OTR) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 254 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 282 (UniProt: P11086)
| PDB | External Database | Details |
|---|---|---|
| Glu 283 | - | expression tag |
| His 284 | - | expression tag |
| His 285 | - | expression tag |
| His 286 | - | expression tag |
| His 287 | - | expression tag |
| His 288 | - | expression tag |
| His 289 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63691.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1170.1 | |
| All* | Total formula weight | 64862.1 |
