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2AMQ

Crystal Structure Of SARS_CoV Mpro in Complex with an Inhibitor N3

Summary for 2AMQ
Entry DOI10.2210/pdb2amq/pdb
Related1UJ1 2AMD 2AMP
Related PRD IDPRD_002214
Descriptor3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
Functional Keywordsanti-parallel b-barrel, anti-parallel a-helices, hydrolase
Biological sourceSARS coronavirus
More
Total number of polymer chains4
Total formula weight69937.75
Authors
Yang, H.,Xue, X.,Yang, K.,Zhao, Q.,Bartlam, M.,Rao, Z. (deposition date: 2005-08-10, release date: 2005-09-13, Last modification date: 2023-11-15)
Primary citationYang, H.,Xie, W.,Xue, X.,Yang, K.,Ma, J.,Liang, W.,Zhao, Q.,Zhou, Z.,Pei, D.,Ziebuhr, J.,Hilgenfeld, R.,Yuen, K.Y.,Wong, L.,Gao, G.,Chen, S.,Chen, Z.,Ma, D.,Bartlam, M.,Rao, Z.
Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3:324-334, 2005
Cited by
PubMed: 16128623
DOI: 10.1371/journal.pbio.0030324
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

数据于2024-03-27公开中

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