Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0019082 | biological_process | viral protein processing |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0019082 | biological_process | viral protein processing |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR CHAIN C OF N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~- ((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3- YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE |
| Chain | Residue |
| A | THR25 |
| A | HIS163 |
| A | HIS164 |
| A | MET165 |
| A | GLU166 |
| A | PRO168 |
| A | HIS172 |
| A | ASP187 |
| A | GLN189 |
| A | THR190 |
| A | GLN192 |
| A | THR26 |
| A | HOH423 |
| C | HOH101 |
| C | HOH102 |
| A | HIS41 |
| A | MET49 |
| A | PHE140 |
| A | LEU141 |
| A | GLY143 |
| A | SER144 |
| A | CYS145 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR CHAIN D OF N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~- ((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3- YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE |
| Chain | Residue |
| B | THR24 |
| B | THR25 |
| B | THR26 |
| B | PHE140 |
| B | GLY143 |
| B | SER144 |
| B | CYS145 |
| B | HIS163 |
| B | HIS164 |
| B | MET165 |
| B | GLU166 |
| B | PRO168 |
| B | HIS172 |
| B | GLN189 |
| B | THR190 |
| D | HOH101 |
| D | HOH102 |
| D | HOH103 |
| D | HOH104 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For 3CL-PRO activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00772","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2bx4 |
| Chain | Residue | Details |
| A | CYS145 | |
| A | HIS41 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2bx4 |
| Chain | Residue | Details |
| B | CYS145 | |
| B | HIS41 | |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 830 |
| Chain | Residue | Details |
| A | HIS41 | proton acceptor, proton donor |
| A | GLY143 | electrostatic stabiliser |
| A | CYS145 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 830 |
| Chain | Residue | Details |
| B | HIS41 | proton acceptor, proton donor |
| B | GLY143 | electrostatic stabiliser |
| B | CYS145 | electrostatic stabiliser |
