2AMD
Crystal Structure Of SARS_CoV Mpro in Complex with an Inhibitor N9
2AMD の概要
エントリーDOI | 10.2210/pdb2amd/pdb |
関連するPDBエントリー | 1UJ1 2AMP 2AMQ |
分子名称 | 3C-like proteinase, N-(3-FUROYL)-D-VALYL-L-VALYL-N~1~-((1R,2Z)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-D-LEUCINAMIDE (3 entities in total) |
機能のキーワード | anti-parallel b-barrel, anti-parallel a-helices, hydrolase |
由来する生物種 | SARS coronavirus |
細胞内の位置 | Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 69839.69 |
構造登録者 | |
主引用文献 | Yang, H.,Xie, W.,Xue, X.,Yang, K.,Ma, J.,Liang, W.,Zhao, Q.,Zhou, Z.,Pei, D.,Ziebuhr, J.,Hilgenfeld, R.,Yuen, K.Y.,Wong, L.,Gao, G.,Chen, S.,Chen, Z.,Ma, D.,Bartlam, M.,Rao, Z. Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases. Plos Biol., 3:324-334, 2005 Cited by PubMed: 16128623DOI: 10.1371/journal.pbio.0030324 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.85 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード