2AJL

X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor

2AJL の概要

• エントリーDOI: 10.2210/pdb2ajl/pdb
• 分子名称: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE, ... (4 entities in total)
• 機能のキーワード: aminopeptidase, hydrolase, protease, serine protease
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 172669.01

構造登録者

Qiao, L.,Baumann, C.A.,Crysler, C.S.,Ninan, N.S.,Abad, M.C.,Spurlino, J.C.,DesJarlais, R.L.,Kervinen, J.,Neeper, M.P.,Bayoumy, S.S. (登録日: 2005-08-02, 公開日: 2005-11-08, 最終更新日: 2023-08-23)

主引用文献

Qiao, L.,Baumann, C.A.,Crysler, C.S.,Ninan, N.S.,Abad, M.C.,Spurlino, J.C.,Desjarlais, R.L.,Kervinen, J.,Neeper, M.P.,Bayoumy, S.S.,Williams, R.,Deckman, I.C.,Dasgupta, M.,Reed, R.L.,Huebert, N.D.,Tomczuk, B.E.,Moriarty, K.J.
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors
Bioorg.Med.Chem.Lett., 16:123-128, 2006

PubMed Abstract: The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.

PubMed: 16236500
DOI: 10.1016/j.bmcl.2005.09.037

実験手法

X-RAY DIFFRACTION (2.5 Å)