2AJC

Porcine dipeptidyl peptidase IV (CD26) in complex with 4-(2-Aminoethyl)-benzene sulphonyl fluoride (AEBSF)

Summary for 2AJC

Entry DOI	10.2210/pdb2ajc/pdb
Related	1ORV 2AJ8 2AJB 2AJD
Descriptor	Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	serine protease, dipeptidyl peptidase, alpha/beta-hydrolase, beta-propeller, oxyanion hole, substrate channeling, drug design, diabetes mellitus, flexibility, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Sus scrofa (pig)
Total number of polymer chains	4
Total formula weight	346376.32
Authors	Engel, M.,Hoffmann, T.,Manhart, S.,Heiser, U.,Chambre, S.,Huber, R.,Demuth, H.U.,Bode, W. (deposition date: 2005-08-01, release date: 2006-02-28, Last modification date: 2023-08-23)
Primary citation	Engel, M.,Hoffmann, T.,Manhart, S.,Heiser, U.,Chambre, S.,Huber, R.,Demuth, H.U.,Bode, W. Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV. J.Mol.Biol., 355:768-783, 2006 Cited by PubMed: 16330047 DOI: 10.1016/j.jmb.2005.11.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation