2AJ8

Porcine dipeptidyl peptidase IV (CD26) in complex with 7-Benzyl-1,3-dimethyl-8-piperazin-1-yl-3,7-dihydro-purine-2,6-dione (BDPX)

2AJ8 の概要

• エントリーDOI: 10.2210/pdb2aj8/pdb
• 関連するPDBエントリー: 2AJB 2AJC 2AJD
• 分子名称: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: serine protease, dipeptidyl peptidase, oxyanion hole, substrate channeling, drug design, diabetes mellitus, flexibility, hydrolase
• 由来する生物種: Sus scrofa (pig)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 348406.70

構造登録者

Engel, M.,Hoffmann, T.,Manhart, S.,Heiser, U.,Chambre, S.,Huber, R.,Demuth, H.U.,Bode, W. (登録日: 2005-08-01, 公開日: 2006-02-28, 最終更新日: 2023-08-23)

• 主引用文献: Engel, M.,Hoffmann, T.,Manhart, S.,Heiser, U.,Chambre, S.,Huber, R.,Demuth, H.U.,Bode, W.; Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.; J.Mol.Biol., 355:768-783, 2006; PubMed: 16330047; DOI: 10.1016/j.jmb.2005.11.014

実験手法

X-RAY DIFFRACTION (2.11 Å)