2AJ8

Porcine dipeptidyl peptidase IV (CD26) in complex with 7-Benzyl-1,3-dimethyl-8-piperazin-1-yl-3,7-dihydro-purine-2,6-dione (BDPX)

Summary for 2AJ8

Entry DOI	10.2210/pdb2aj8/pdb
Related	2AJB 2AJC 2AJD
Descriptor	Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	serine protease, dipeptidyl peptidase, oxyanion hole, substrate channeling, drug design, diabetes mellitus, flexibility, hydrolase
Biological source	Sus scrofa (pig)
Total number of polymer chains	4
Total formula weight	348406.70
Authors	Engel, M.,Hoffmann, T.,Manhart, S.,Heiser, U.,Chambre, S.,Huber, R.,Demuth, H.U.,Bode, W. (deposition date: 2005-08-01, release date: 2006-02-28, Last modification date: 2023-08-23)
Primary citation	Engel, M.,Hoffmann, T.,Manhart, S.,Heiser, U.,Chambre, S.,Huber, R.,Demuth, H.U.,Bode, W. Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV. J.Mol.Biol., 355:768-783, 2006 Cited by PubMed: 16330047 DOI: 10.1016/j.jmb.2005.11.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation