2AIK

Formylglycine generating enzyme C336S mutant covalently bound to substrate peptide LCTPSRA

2AIK の概要

• エントリーDOI: 10.2210/pdb2aik/pdb
• 関連するPDBエントリー: 2AII 2AIJ
• 分子名称: Sulfatase modifying factor 1, LCTPSRA peptide from Arylsulfatase A, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: formylglycine, post-translational modification, endoplasmic reticulum, sulfatase, hydrolase activator, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Endoplasmic reticulum lumen: Q8NBK3; Lysosome: P15289
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33398.51

構造登録者

Roeser, D.,Rudolph, M.G. (登録日: 2005-07-29, 公開日: 2005-12-13, 最終更新日: 2023-10-25)

• 主引用文献: Roeser, D.,Preusser-Kunze, A.,Schmidt, B.,Gasow, K.,Wittmann, J.G.,Dierks, T.,von Figura, K.,Rudolph, M.G.; A general binding mechanism for all human sulfatases by the formylglycine-generating enzyme; Proc.Natl.Acad.Sci.Usa, 103:81-86, 2006; PubMed: 16368756; DOI: 10.1073/pnas.0507592102

実験手法

X-RAY DIFFRACTION (1.73 Å)