2AHM

Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer

2AHM の概要

• エントリーDOI: 10.2210/pdb2ahm/pdb
• 分子名称: Replicase polyprotein 1ab, light chain, Replicase polyprotein 1ab, heavy chain, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: sars-cov, coronavirus, non-structural protein, nsp7, nsp8, super-complex, hexadecamer, viral protein, replication
• 由来する生物種: SARS coronavirus; 詳細
• 細胞内の位置: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641 P59641
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 128507.40

構造登録者

Zhai, Y.J.,Sun, F.,Bartlam, M.,Rao, Z. (登録日: 2005-07-28, 公開日: 2005-11-15, 最終更新日: 2024-03-13)

• 主引用文献: Zhai, Y.J.,Sun, F.,Li, X.,Pang, H.,Xu, X.,Bartlam, M.,Rao, Z.; Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer; NAT.STRUCT.MOL.BIOL., 12:980-986, 2005; PubMed: 16228002; DOI: 10.1038/nsmb999

実験手法

X-RAY DIFFRACTION (2.4 Å)