2AGI

The leupeptin-trypsin covalent complex at 1.14 A resolution

Summary for 2AGI

• Entry DOI: 10.2210/pdb2agi/pdb
• Related: 2AGE 2AGG 2AH4
• Related PRD ID: PRD_000216
• Descriptor: beta-trypsin, leupeptin, SULFATE ION, ... (5 entities in total)
• Functional Keywords: acyl-enzyme, serine protease, proteinase, peptidase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Bos taurus (cattle); More
• Cellular location: Secreted, extracellular space: P00760
• Total number of polymer chains: 2
• Total formula weight: 23986.07

Authors

Radisky, E.S.,Lee, J.M.,Lu, C.J.,Koshland Jr., D.E. (deposition date: 2005-07-26, release date: 2006-05-16, Last modification date: 2023-08-23)

• Primary citation: Radisky, E.S.,Lee, J.M.,Lu, C.J.,Koshland Jr., D.E.; Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates; Proc.Natl.Acad.Sci.USA, 103:6835-6840, 2006; PubMed: 16636277; DOI: 10.1073/pnas.0601910103

Experimental method

X-RAY DIFFRACTION (1.14 Å)