2AE5

Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism

Summary for 2AE5

Entry DOI	10.2210/pdb2ae5/pdb
Related	2ADV 2AE3 2AE4
Descriptor	Glutaryl 7-Aminocephalosporanic Acid Acylase, GLYCEROL, SULFATE ION, ... (5 entities in total)
Functional Keywords	autoproteolysis, precursor activation, intermediate structure, cephalosporin acylase, hydrolase
Biological source	Pseudomonas sp. More
Total number of polymer chains	2
Total formula weight	77578.97
Authors	Kim, J.K.,Yang, I.S.,Shin, H.J.,Cho, K.J.,Ryu, E.K.,Kim, S.H.,Park, S.S.,Kim, K.H. (deposition date: 2005-07-21, release date: 2006-01-24, Last modification date: 2024-03-13)
Primary citation	Kim, J.K.,Yang, I.S.,Shin, H.J.,Cho, K.J.,Ryu, E.K.,Kim, S.H.,Park, S.S.,Kim, K.H. Insight into autoproteolytic activation from the structure of cephalosporin acylase: a protein with two proteolytic chemistries. Proc.Natl.Acad.Sci.USA, 103:1732-1737, 2006 Cited by PubMed: 16446446 DOI: 10.1073/pnas.0507862103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation