2ADF
Crystal Structure and Paratope Determination of 82D6A3, an Antithrombotic Antibody Directed Against the von Willebrand factor A3-Domain
Summary for 2ADF
Entry DOI | 10.2210/pdb2adf/pdb |
Descriptor | Von Willebrand factor, 82D6A3 IgG, ACETIC ACID, ... (7 entities in total) |
Functional Keywords | on willebrand factor, a3-domain, 82d6a3, collagen binding, paratope, epitope, antithrombotic, blood clotting-immune system complex, blood clotting/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P04275 P84751 |
Total number of polymer chains | 3 |
Total formula weight | 67880.02 |
Authors | Staelens, S.,Hadders, M.A.,Vauterin, S.,Platteau, C.,Vanhoorelbeke, K.,Huizinga, E.G.,Deckmyn, H. (deposition date: 2005-07-20, release date: 2005-12-06, Last modification date: 2023-10-25) |
Primary citation | Staelens, S.,Hadders, M.A.,Vauterin, S.,Platteau, C.,De Maeyer, M.,Vanhoorelbeke, K.,Huizinga, E.G.,Deckmyn, H. Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain J.Biol.Chem., 281:2225-2231, 2006 Cited by PubMed: 16314412DOI: 10.1074/jbc.M508191200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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