2ACZ

Complex II (Succinate Dehydrogenase) From E. Coli with Atpenin A5 inhibitor co-crystallized at the ubiquinone binding site

2ACZ の概要

• エントリーDOI: 10.2210/pdb2acz/pdb
• 関連するPDBエントリー: 1NEK 1NEN 2AD0
• 分子名称: Succinate dehydrogenase flavoprotein subunit, HEME B/C, 3-[(2S,4S,5R)-5,6-DICHLORO-2,4-DIMETHYL-1-OXOHEXYL]-4-HYDROXY-5,6-DIMETHOXY-2(1H)-PYRIDINONE, ... (12 entities in total)
• 機能のキーワード: membrane protein, aerobic reparatory complex ii, sqr, succinate:ubiquinone oxidoreductase, aa5, at5, atpenin a5, sdh, succinate dehydrogenase, oxidoreductase-electron transport complex, oxidoreductase/electron transport
• 由来する生物種: Escherichia coli; 詳細
• 細胞内の位置: Cell inner membrane ; Peripheral membrane protein : P07014; Cell inner membrane; Multi-pass membrane protein: P69054
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 122367.34

構造登録者

Horsefield, R.,Yankovskaya, V.,Sexton, G.,Whittingham, W.,Shiomi, K.,Omura, S.,Byrne, B.,Cecchini, G.,Iwata, S. (登録日: 2005-07-19, 公開日: 2006-01-03, 最終更新日: 2023-10-25)

• 主引用文献: Horsefield, R.,Yankovskaya, V.,Sexton, G.,Whittingham, W.,Shiomi, K.,Omura, S.,Byrne, B.,Cecchini, G.,Iwata, S.; Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction.; J.Biol.Chem., 281:7309-7316, 2006; PubMed: 16407191; DOI: 10.1074/jbc.M508173200

実験手法

X-RAY DIFFRACTION (3.1 Å)