2ACS
AN ANION BINDING SITE IN HUMAN ALDOSE REDUCTASE: MECHANISTIC IMPLICATIONS FOR THE BINDING OF CITRATE, CACODYLATE, AND GLUCOSE-6-PHOSPHATE
Summary for 2ACS
Entry DOI | 10.2210/pdb2acs/pdb |
Descriptor | ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ... (4 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 36702.67 |
Authors | Harrison, D.H.,Bohren, K.M.,Gabbay, K.H.,Petsko, G.A.,Ringe, D. (deposition date: 1994-04-15, release date: 1994-07-31, Last modification date: 2024-02-14) |
Primary citation | Harrison, D.H.,Bohren, K.M.,Ringe, D.,Petsko, G.A.,Gabbay, K.H. An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate. Biochemistry, 33:2011-2020, 1994 Cited by PubMed: 8117658DOI: 10.1021/bi00174a006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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