2A9I

Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain

Summary for 2A9I

• Entry DOI: 10.2210/pdb2a9i/pdb
• Descriptor: Interleukin-1 receptor-associated kinase-4, MANGANESE (II) ION (3 entities in total)
• Functional Keywords: hexahelical bundle, transferase
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 1
• Total formula weight: 12719.59

Authors

Lasker, M.V.,Gajjar, M.M.,Nair, S.K. (deposition date: 2005-07-11, release date: 2005-10-11, Last modification date: 2024-02-14)

Primary citation

Lasker, M.V.,Gajjar, M.M.,Nair, S.K.
Cutting Edge: Molecular Structure of the IL-1R-Associated Kinase-4 Death Domain and Its Implications for TLR Signaling.
J.Immunol., 175:4175-4179, 2005

PubMed Abstract: IL-1R-associated kinase (IRAK) 4 is an essential component of innate immunity. IRAK-4 deficiency in mice and humans results in severe impairment of IL-1 and TLR signaling. We have solved the crystal structure for the death domain of Mus musculus IRAK-4 to 1.7 A resolution. This is the first glimpse of the structural details of a mammalian IRAK family member. The crystal structure reveals a six-helical bundle with a prominent loop, which among IRAKs and Pelle, a Drosophila homologue, is unique to IRAK-4. This highly structured loop contained between helices two and three, comprises an 11-aa stretch. Although innate immune domain recognition is thought to be very similar between Drosophila and mammals, this structural component points to a drastic difference. This structure can be used as a framework for future mutation and deletion studies and potential drug design.

PubMed: 16177054

Experimental method

X-RAY DIFFRACTION (1.7 Å)