2A8W

Crystal Structure of Human N-acetylgalactosaminyltransferase (GTA) Complexed with Beta-Methyllactoside

2A8W の概要

• エントリーDOI: 10.2210/pdb2a8w/pdb
• 関連するPDBエントリー: 1ZHJ 1ZI1 1ZI3 1ZI4 1ZI5 1ZJO
• 分子名称: Histo-blood group ABO system transferase (NAGAT) [Includes: Glycoprotein-fucosylgalactoside alpha-N- acetylgalactosaminyltransferase (EC 2.4.1.40) (Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase) (Histo-blood group A transferase) (A transferase); Glycoprotein-fucosylgalactoside alpha- galactosyltransferase (EC 2.4.1.37) (Fucosylglycoprotein 3-alpha- galactosyltransferase) (Histo-blood group B transferase) (B transferase)] [Contains: Fucosylglycoprotein alpha-N- acetylgalactosaminyltransferase, soluble form], MERCURY (II) ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: gta, abo(h), blood groups, glycosyltransferase, retaining, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein: P16442
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35692.00

構造登録者

Letts, J.A.,Rose, N.L.,Fang, Y.R.,Barry, C.H.,Borisova, S.N.,Seto, N.O.,Palcic, M.M.,Evans, S.V. (登録日: 2005-07-09, 公開日: 2005-12-13, 最終更新日: 2023-08-23)

• 主引用文献: Letts, J.A.,Rose, N.L.,Fang, Y.R.,Barry, C.H.,Borisova, S.N.,Seto, N.O.,Palcic, M.M.,Evans, S.V.; Differential Recognition of the Type I and II H Antigen Acceptors by the Human ABO(H) Blood Group A and B Glycosyltransferases.; J.Biol.Chem., 281:3625-3632, 2006; PubMed: 16326711; DOI: 10.1074/jbc.M507620200

実験手法

X-RAY DIFFRACTION (1.59 Å)