2A69

Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin

2A69 の概要

• エントリーDOI: 10.2210/pdb2a69/pdb
• 関連するPDBエントリー: 1A6E 1A6H 1IW7 1SMY 2A68
• 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... (9 entities in total)
• 機能のキーワード: rna polymerase holoenzyme, rifapentin, antibiotic, transcription regulation, riken structural genomics/proteomics initiative, rsgi, structural genomics, transferase
• 由来する生物種: Thermus thermophilus; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 867123.21

構造登録者

Artsimovitch, I.,Vassylyeva, M.N.,Svetlov, D.,Svetlov, V.,Perederina, A.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Tahirov, T.H.,Vassylyev, D.G.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2005-07-02, 公開日: 2005-09-20, 最終更新日: 2023-08-23)

• 主引用文献: Artsimovitch, I.,Vassylyeva, M.N.,Svetlov, D.,Svetlov, V.,Perederina, A.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Tahirov, T.H.,Vassylyev, D.G.; Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.; Cell(Cambridge,Mass.), 122:351-363, 2005; PubMed: 16096056; DOI: 10.1016/j.cell.2005.07.014

実験手法

X-RAY DIFFRACTION (2.5 Å)