2A5P

Monomeric parallel-stranded DNA tetraplex with snap-back 3+1 3' G-tetrad, single-residue chain reversal loops, GAG triad in the context of GAAG diagonal loop, NMR, 8 struct.

Summary for 2A5P

• Entry DOI: 10.2210/pdb2a5p/pdb
• Related: 1D6D 1EEG 1JJP 1Y8D 2A5R
• Descriptor: 5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*IP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*G)-3' (1 entity in total)
• Functional Keywords: monomeric parallel-stranded quadruplex; c-myc promoter 3+1 g-tetrad; single nucleotide chain reversal loop; gag triad; gaag loop, dna
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 7701.93

Authors

Phan, A.T.,Kuryavyi, V.V.,Gaw, H.Y.,Patel, D.J. (deposition date: 2005-06-30, release date: 2005-07-26, Last modification date: 2022-03-09)

• Primary citation: Phan, A.T.,Kuryavyi, V.,Gaw, H.Y.,Patel, D.J.; Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter.; Nat.Chem.Biol., 1:167-173, 2005; PubMed: 16408022; DOI: 10.1038/nchembio723

Experimental method

SOLUTION NMR