2A49

Crystal structure of clavulanic acid bound to E166A variant of SHV-1 beta-lactamase

Summary for 2A49

Entry DOI	10.2210/pdb2a49/pdb
Related	1rcj 2A3U
Descriptor	Beta-lactamase SHV-1, N-(2-HYDROXY-4-OXO-BUTYL)-N-(3-OXO-TRANSPROPENYL)AMINE, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (5 entities in total)
Functional Keywords	beta-lactamase, beta-lactam hydrolase, penicillinase, detergent binding, inhibitor design, covalent intermediate, hydrolase
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	30732.32
Authors	Padayatti, P.S.,Helfand, M.S.,Totir, M.A.,Carey, M.P.,Carey, P.R.,Bonomo, R.A.,van den Akker, F. (deposition date: 2005-06-28, release date: 2005-08-02, Last modification date: 2021-10-20)
Primary citation	Padayatti, P.S.,Helfand, M.S.,Totir, M.A.,Carey, M.P.,Carey, P.R.,Bonomo, R.A.,van den Akker, F. High Resolution Crystal Structures of the trans-Enamine Intermediates Formed by Sulbactam and Clavulanic Acid and E166A SHV-1 {beta}-Lactamase. J.Biol.Chem., 280:34900-34907, 2005 Cited by PubMed: 16055923 DOI: 10.1074/jbc.M505333200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.43 Å)

Structure validation