2A2J

Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis

2A2J の概要

• エントリーDOI: 10.2210/pdb2a2j/pdb
• 分子名称: Pyridoxamine 5'-phosphate oxidase (2 entities in total)
• 機能のキーワード: beta barrel, structural genomics, mycobacterium tuberculosis structural proteomics project, xmtb, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55211.77

構造登録者

Pedelacq, J.-D.,Rho, B.-S.,Kim, C.-Y.,Waldo, G.S.,Lekin, T.P.,Segelke, B.W.,Rupp, B.,Hung, L.-W.,Kim, S.-I.,Terwilliger, T.C.,Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) (登録日: 2005-06-22, 公開日: 2005-08-23, 最終更新日: 2024-10-09)

主引用文献

Pedelacq, J.-D.,Rho, B.-S.,Kim, C.-Y.,Waldo, G.S.,Lekin, T.P.,Segelke, B.W.,Rupp, B.,Hung, L.-W.,Kim, S.-I.,Terwilliger, T.C.
Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis.
Proteins, 62:563-569, 2005

PubMed Abstract: The three-dimensional structure of Rv2607, a putative pyridoxine 5'-phosphate oxidase (PNPOx) from Mycobacterium tuberculosis, has been determined by X-ray crystallography to 2.5 A resolution. Rv2607 has a core domain similar to known PNPOx structures with a flavin mononucleotide (FMN) cofactor. Electron density for two FMN at the dimer interface is weak despite the bright yellow color of the protein solution and crystal. The shape and size of the putative binding pocket is markedly different from that of members of the PNPOx family, which may indicate some significant changes in the FMN binding mode of this protein relative to members of the family.

PubMed: 16374842
DOI: 10.1002/prot.20824

実験手法

X-RAY DIFFRACTION (2.5 Å)