2A1H
X-ray crystal structure of human mitochondrial branched chain aminotransferase (BCATm) complexed with gabapentin
Summary for 2A1H
Entry DOI | 10.2210/pdb2a1h/pdb |
Related | 1EKF 1EKP 1EKV 1KT8 1KTA |
Descriptor | branched chain aminotransferase, PYRIDOXAL-5'-PHOSPHATE, [1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID, ... (5 entities in total) |
Functional Keywords | fold type iv, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Isoform A: Mitochondrion. Isoform B: Cytoplasm: O15382 |
Total number of polymer chains | 2 |
Total formula weight | 83632.84 |
Authors | Goto, M.,Miyahara, I.,Hirotsu, K.,Conway, M.,Yennawar, N.,Islam, M.M.,Hutson, S.M. (deposition date: 2005-06-20, release date: 2005-09-06, Last modification date: 2017-10-11) |
Primary citation | Goto, M.,Miyahara, I.,Hirotsu, K.,Conway, M.,Yennawar, N.,Islam, M.M.,Hutson, S.M. Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin. J.Biol.Chem., 280:37246-37256, 2005 Cited by PubMed: 16141215DOI: 10.1074/jbc.M506486200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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