2A0C

Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor

2A0C の概要

• エントリーDOI: 10.2210/pdb2a0c/pdb
• 分子名称: Cell division protein kinase 2, 2-{[(2-{[(1R)-1-(HYDROXYMETHYL)PROPYL]AMINO}-9-ISOPROPYL-9H-PURIN-6-YL)AMINO]METHYL}PHENOL (3 entities in total)
• 機能のキーワード: protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase, serine/threonine-protein kinase, atp-binding
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34346.94

構造登録者

Krystof, V.,McNae, I.W.,Walkinshaw, M.D.,Fischer, P.M.,Muller, P.,Vojtesek, B.,Orsag, M.,Havlicek, L.,Strnad, M. (登録日: 2005-06-16, 公開日: 2006-01-24, 最終更新日: 2024-03-13)

• 主引用文献: Krystof, V.,McNae, I.W.,Walkinshaw, M.D.,Fischer, P.M.,Muller, P.,Vojtesek, B.,Orsag, M.,Havlicek, L.,Strnad, M.; Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor; Cell.Mol.Life Sci., 62:1763-1771, 2005; PubMed: 16003486; DOI: 10.1007/s00018-005-5185-1

実験手法

X-RAY DIFFRACTION (1.95 Å)