2ZNH
Crystal Structure of a Domain-Swapped Serpin Dimer
Summary for 2ZNH
Entry DOI | 10.2210/pdb2znh/pdb |
Descriptor | Antithrombin-III, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | domain-swap, blood coagulation, disease mutation, glycoprotein, heparin-binding, protease inhibitor, secreted, serine protease inhibitor, thrombophilia, blood clotting |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted, extracellular space: P01008 |
Total number of polymer chains | 2 |
Total formula weight | 100626.18 |
Authors | Yamasaki, M.,Huntington, J.A. (deposition date: 2008-04-25, release date: 2008-10-21, Last modification date: 2023-11-01) |
Primary citation | Yamasaki, M.,Li, W.,Johnson, D.J.,Huntington, J.A. Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization Nature, 455:1255-1258, 2008 Cited by PubMed: 18923394DOI: 10.1038/nature07394 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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