2ZLA
2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation and crystal structure
Summary for 2ZLA
Entry DOI | 10.2210/pdb2zla/pdb |
Related | 2ZL9 2ZLC |
Descriptor | Vitamin D3 receptor, Coactivator peptide DRIP, (1R,2S,3R,5Z,7E)-17-{(1R)-1-[(2-ethyl-2-hydroxybutyl)sulfanyl]ethyl}-2-(2-hydroxyethoxy)-9,10-secoestra-5,7,16-triene-1,3-diol, ... (4 entities in total) |
Functional Keywords | protein-ligand complex, dna-binding, metal-binding, nucleus, phosphoprotein, receptor, transcription, transcription regulation, zinc, zinc-finger, hormone |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Nucleus: P13053 |
Total number of polymer chains | 2 |
Total formula weight | 32660.66 |
Authors | Shimizu, M.,Miyamoto, Y.,Nakabayashi, M.,Masuno, H.,Ikura, T.,Ito, N. (deposition date: 2008-04-04, release date: 2008-06-24, Last modification date: 2023-11-01) |
Primary citation | Shimizu, M.,Miyamoto, Y.,Takaku, H.,Matsuo, M.,Nakabayashi, M.,Masuno, H.,Udagawa, N.,DeLuca, H.F.,Ikura, T.,Ito, N. 2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation, and crystal structure Bioorg.Med.Chem., 16:6949-6964, 2008 Cited by PubMed: 18539034DOI: 10.1016/j.bmc.2008.05.043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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