2ZK6

Human peroxisome proliferator-activated receptor gamma ligand binding domain complexed with C8-BODIPY

Summary for 2ZK6

Entry DOI	10.2210/pdb2zk6/pdb
Related	2ZK0 2ZK1 2ZK2 2ZK3 2ZK4 2ZK5
Descriptor	Peroxisome proliferator-activated receptor gamma, difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron (3 entities in total)
Functional Keywords	anti parallel helix sandwich, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	65869.91
Authors	Waku, T.,Shiraki, T.,Oyama, T.,Fujimoto, Y.,Morikawa, K. (deposition date: 2008-03-12, release date: 2009-02-24, Last modification date: 2023-11-01)
Primary citation	Waku, T.,Shiraki, T.,Oyama, T.,Maebara, K.,Nakamori, R.,Morikawa, K. The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites Embo J., 29:3395-3407, 2010 Cited by PubMed: 20717101 DOI: 10.1038/emboj.2010.197 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.41 Å)

Structure validation