2Z3Y

Crystal structure of Lysine-specific demethylase1

Summary for 2Z3Y

Entry DOI	10.2210/pdb2z3y/pdb
Related	2EJR 2Z5U
Descriptor	Lysine-specific histone demethylase 1, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-5-[7,8-DIMETHYL-2,4-DIOXO-5-(3-PHENYLPROPANOYL)-1,3,4,5-TETRAHYDROBENZO[G]PTERIDIN-10(2H)-YL]-2,3,4-TRIHYDROXYPENTYL DIHYDROGEN DIPHOSPHATE (3 entities in total)
Functional Keywords	chromatin, histone demethylase, nucleosome, transcription, lsd1, lysine-specific, alternative splicing, chromatin regulator, coiled coil, fad, nucleus, oxidoreductase, phosphorylation, repressor, transcription regulation, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O60341
Total number of polymer chains	1
Total formula weight	74571.97
Authors	Mimasu, S.,Sengoku, T.,Umehara, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2007-06-08, release date: 2008-01-01, Last modification date: 2024-03-13)
Primary citation	Mimasu, S.,Sengoku, T.,Fukuzawa, S.,Umehara, T.,Yokoyama, S. Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25A Biochem.Biophys.Res.Commun., 366:15-22, 2008 Cited by PubMed: 18039463 DOI: 10.1016/j.bbrc.2007.11.066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation