2YGQ
WIF domain-epidermal growth factor (EGF)-like domains 1-3 of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine
Summary for 2YGQ
Entry DOI | 10.2210/pdb2ygq/pdb |
Related | 2YGN 2YGO 2YGP |
Related PRD ID | PRD_900013 |
Descriptor | WNT INHIBITORY FACTOR 1, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, ... (5 entities in total) |
Functional Keywords | signaling protein, wnt signaling pathway, wnt antagonist, morphogen, cancer, glycosaminoglycan |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Secreted: Q9Y5W5 |
Total number of polymer chains | 1 |
Total formula weight | 37725.04 |
Authors | Malinauskas, T.,Aricescu, A.R.,Lu, W.,Siebold, C.,Jones, E.Y. (deposition date: 2011-04-19, release date: 2011-07-13, Last modification date: 2020-07-29) |
Primary citation | Malinauskas, T.,Aricescu, A.R.,Lu, W.,Siebold, C.,Jones, E.Y. Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1 Nat.Struct.Mol.Biol., 18:886-, 2011 Cited by PubMed: 21743455DOI: 10.1038/NSMB.2081 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.951 Å) |
Structure validation
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